Vascularization Challenge



  • Determine novel glomerular capillary structure and function.​

    • PART 1: Autoregulation of glomerular flow.
    • PART 2: Size- and charge-selective barrier function of glomerular basement membrane interface.
    • PART 3: Glomerular filtration alters both glomerular and post-glomerular capillary Starling forces. Normal glomeruli filter as much as 180 L plasma/day (125 mL/min). The corresponding post-glomerular Starling forces facilitate the reabsorption of…

  • Cortical peritubular capillaries, which arise from cortical glomeruli, play crucial roles in the bulk reabsorption of filtered water, electrolytes, and nutrients in the proximal tubule. We need to understand this system better. <Added to control of cellular microfluidics>

    • PART 1: Fluid movement out of the renal capillary beds is subject to the same Starling forces that govern extra-capillary fluid movement in other capillary beds.

  • Medullary vasa recta arise from juxtamedullary glomeruli and differ both structurally and functionally from cortical peritubular capillaries, but the general relationships between post-glomerular Starling forces and both glomerular capillary plasma flow and glomerular filtration resemble those observed in the cortex. The vasa recta form hairpin loops within the medulla that parallel Henle’s loops associated with juxtaglomerular nephrons. Reduced flow characteristics critical for vasa recta function.

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