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Musculoskeletal - New Organ Alliance

Vascularization Challenges



  • Improve Mechanisms to Align Orientation of Host Tissues with Grafts: muscle and bone are anisotropic structures, and any engineered tissue graft must be aligned appropriately. Improvements in technology to ensure proper connections are needed.
  • Improve Understanding of Mechanical Loading Environment: for bone mesenchymal stem cells loading is important in differentiation, and may play a role in how bone and muscle develop, including placement of vascular networks.

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