Creation of multiscale and multiphenotype vascular networks in cubic centimeter volumes.
Perfusion of engineered vascular networks. Perfusion must also include energy and oxygen rich perfusate.
Understand the cross talk between cardiomyocytes and vascular cells, and leverage these interactions to rapidly obtain more comprehensive vascular networks.
Understand relationship between cardiomyocyte functional parameters and vasculature: when and how much vascularization is required for cardiomyocytes conduction and contraction?