Liver
Cell Sourcing Challenges

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liver
sub-challenges

Improve understanding of the cultureability of hepatocytes and the limitations of producing hepatocytes in a culture. This requires new techniques to expand cells that do not currently expand.
Develop methods to isolate and identify tissue specific stem/progenitor cells.
Understand how to drive differentiation to hepatocytes, Cholangiocytes, and others.
Criteria for successful cell survival and expansion are required.
Media choice to keep all cells expanding/functioning though a heparinized blood analogue would be very useful. Cells will need to be adapted to blood prior to implantation.