Through previous road-mapping workshops and reviews, the New Organ Alliance has structured Road-mapping Committees for each of the major solid organs. Organ Engineering Committees currently include: Cardiovascular, Muscle, Liver, and Kidney focuses. In the Road-map structure, we identify challenge topics and sub-challenges as either “Cross-Cutting” between multiple organs, or specific to an individual organ. These are noted in the challenge topic sections themselves. Details on the need for new bioengineering technologies and the current state of the art are noted in the overview statements from each committee below as well as the current committee focus areas.