Logistics discussion

• Welcome to NASA Ames (view video)
  • Dr. Steven Zornetzer, Associate Director for Research and Technology, NASA Ames Research Center
    
    

• Introduction to NASA's Centennial Challenges Program (view video)
  
  • Monsi Roman, Director, NASA Centennial Challenges Program
    
    
• Introduction to the CASIS Innovations in Space Award (view video)
  
  • Jana Stoudemire, Life Sciences Lead, CASIS
    
    
• Methuselah Foundation - Investing to extend healthy life (view video)
  
  • David Gobel, CEO, Methuselah Foundation
    
    
• Introduction to the New Organ Alliance (view video)
  
  • Joshua Neubert, Managing Partner, New Organ Alliance
    
    
• A Roadmap to End the Organ Shortage (view video)
  
  • Introduction to the New Organ Alliance's Roadmapping Initiative and our workshop's roundtables discussions and goals
    • Dr. Scott Collins, CTO TeVido Biodevices; New Organ Alliance Advisory Board

CHAIR JOSHUA NEUBERT

• Developing Organovo's Commercial Tissues (view video)
  • Dr. Keith Murphy, CEO, Organovo
    
    

• Roadmapping Roundtable Discussions 1: Challenges in Achieving Thick Tissue Vascularization
  • During this first Roadmapping session we will discuss the current state-of-the-art technologies and identify the research pathways and challenges in achieving thick-tissue vascularization. We will identify specific challenges still remaining on the path toward thick-tissue vascularization
    • Roundtable Facilitators lead discussions at tables.
      
      

• Overview of technologies advancing additive manufacturing for health. (view video)
  • The fabrication of thick-tissues with embedded vascular networks is of great importance to advancing tissue engineering, this presentation will provide an overview of how 3D bioprinting technologies are advancing in this area.
    • Dr. Yong Huang, University of Florida

CHAIR MONSI ROMAN

The Challenges of Vascularizing Engineered Heart Tissue

• Dr. Ming-Sing Si, University of Michigan, VTC Team Leader
  
  

Wake Forest University's Bioprinting Capabilities

• Dr. Sang-jin Lee, Wake Forest University, VTC Team Leader
  
  

Penn State University, VTC Team Presentation

• Dr. Ibrahim Ozbolat, Penn State University, VTC Team Leader

CHAIR SCOTT COLLINS

Roadmapping Roundtables 2: Overcoming the Challenges

• This Roadmapping session will explore the specific tools and techniques that researchers may use to overcome the challenges along each research pathway to achieve thick-tissue vascularization, and begin looking beyond this technology toward its end-products for use in the marketplace.
  • Roundtable Facilitators lead discussions at tables

• Florida Institute of Technology, VTC Team Presentation (view video)
  • Dr. Kunal Mitra, Florida Institute of Technology, VTC Team Leader
    
    

• Rice University, VTC Team Presentation
  • Dr. Jordan Miller, Rice University, VTC Team Leader

CHAIR SCOTT COLLINS

• Roundtable Discussions 3: Beyond Thick Tissue Vascularization 
  • This Roadmapping session will focus discussions on defining End-Products for tissue engineering technologies and their benefits and applications. Discussions will also focus on defining the research pathways available in using thick-tissue vascularization technologies to get to these end-product and explore how current research efforts in achieving thick-tissue vascularization could impact the future opportunities to get to specific end-products.
    • Roundtable Facilitators lead discussions at tables

CHAIR JANA STOUDEMIRE

• Panel: CASIS Innovations in Space Award & other Opportunities with Microgravity (view video)
  • This panel explores key scientific results from past microgravity research, and helps workshop participants understand how the microgravity environment may benefit their future tissue engineering research. We will also examine new research opportunities in microgravity such as the "CASIS Innovations in Space Award" and will help tissue engineering researchers understand how to take advantage of these opportunities.
    • Jana Stoudemire, CASIS (Moderator)
      • Dr. Michael Roberts, Deputy Chief Scientist, CASIS
      • Dr. Kirt Costello, NASA

CHAIR IOANA COZMUTA

• Panel: Alternative Opportunities with Computer Modeling, Imaging and Data Analytics. (view video)
  • Tissue engineering research is ultimately an integrative biomedicine problem that’s becoming more and more reliant on multiple sources of information spanning image acquisition and processing, mathematical and computational models of biological systems (from tissue level to cell level and ultimately to the molecular level), genomic patterns, clinical pathology, personalized health records, etc. These sources of information create extremely large data sets and require innovative analytic approaches and tools to extract meaningful information. This panel will discuss how computer modeling, advanced imaging, big-data, machine learning, and other innovative areas of technology provide future opportunities and solutions of relevance to tissue engineering research and in particular to the Vascular Tissue Challenge.
    • Dr. Ioana Cozmuta (Moderator)
      • Dr. Liesbet Geris, Virtual Physiological Human
      • Dr. Patricia Parsons-Wingerter, NASA
      • Kaiser Permanente (Invited)

JOSHUA NEUBERT

• Roadmap Review from Roundtable Chairs (view video)
  • Roundtable chairs and facilitators will share key points about the challenges, research pathways, and opportunities from their previous discussions.
    • Roundtable Chairs

CHAIR LINA CONSTANTINOVICI

• Panel: Challenges in Funding the Future of Tissue Engineering (view video)
  • Startup companies and research groups discuss some of the challenges in getting the funding needed to get to the end goals of thick-tissue engineering. How are they trying to overcome this and what are the key challenges in the way?
    • Lina Constantinovici (Moderator)
      • Dr. Maria Rapoza, Duke University
      • Dr. Scott Collins, TeVido Biodevices
        
        

• Roundtables: Discussion on challenges funding
  • Discussions and Q&A about how we can improve the funding landscape to start getting more research to the product stage.
    • Roundtable Chairs
      
      

• Panel: Government Funding Model Case Studies (view video)
  • This session will explore how research in tissue engineering is currently being supported by government agencies. It will explore alternative/non-traditional funding models, and how to overcome the challenges in support to get thick-tissue engineering to its end-products.
    • Lina Constantinovici (Moderator)
      • Dr. Michele Grimm, NSF BME
      • Dr. Martha Lundberg, NIH NHLBI
      • Dr. Lucie Low, NIH NCATS
      • Dr. Wendy Dean, DoD USAMRMC
      • Dr. Seila Selimovic, NIH NIBIB
        
        

• Roundtables: Discussions on Government funding models
  • Discussions and Q&A about how we can improve the funding landscape to start getting more research to the product stage.
    • Roundtable Chairs
      
      
• Panel: Investor & Philanthropy Funding Model Case Studies
  • This session will explore how research in tissue engineering is currently being supported by philanthropies and investors. It will explore alternative/non-traditional funding, and how to overcome the challenges in support to get thick-tissue engineering to its end-products.
    • Lina Constantinovici (Moderator)
      • David Gobel, Methuselah Foundation
      • Lux Research (Invited)
      • Other Investors & Philanthropic leaders
        
        
• Roundtable Discussions: Discussions on enhancing the funding landscape with investors and philanthropists
  • Discussions and Q&A about how we can improve the funding landscape to start getting more research to the product stage.
    • Roundtable Chairs

• Roundtable Discussions: Take-away points and next step opportunities
  • Closing review of next steps and key summary of points. Have everyone at the roundtables go around a circle and discuss key take-away points, and next step action items they would like to see with this Roadmapping initiative and the VT Challenge work.
    • Roundtable Chairs
      
      

• New Organ Alliance & VT Challenge pathways forward (view video)
  • Closing information about New Organ Alliance and VT Challenge next steps.
    • Joshua Neubert, Managing Partner, New Organ Alliance