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2016 Vascular Tissue Challenge Road-Mapping Workshop - New Organ Alliance

2016 VASCULAR CHALLENGE
ROADMAPPING WORKSHOP

Held on November 9-10, 2016, at the

Nasa Ames Research Park, Mountain View, California

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The Vascular Tissue Challenge Roadmapping Workshop examined in great detail the state of the art technology in thick-tissue vascularization and 3D tissue engineering. As well as mapping out the pathways, milestones, and challenges towards ending the organ shortage benefiting from these technologies. 

The goal of this workshop was to guide future research efforts and encourage new support in bringing about the end-product technologies for patients in need. 

The workshop gathered together a diverse network of experts in tissue engineering, microgravity research, and other areas of interest to the advancement of tissue engineering technology. Throughout the two-day workshop, we enjoyed hearing from leading researchers who are working hard to advance this state of the art technology. These subject matter experts also participated in various roundtable discussions to identify the challenges, map out the future pathways, and milestones that would take us to the ultimate solution. 

We greatly benefited from the their vast knowledge and expertise during the entire workshop. We are confident that you will too. Please click on the links below to enjoy a few highlights from the Vascular Tissue Challenge Roadmapping Workshop.

Beta Roadmap Report from the December 2014 - July 2015 Roadmapping Process including the the NSF-Funded Washington D.C. Workshop & White House Roundtable.

Workshop Recap

Day 1

OPENING PROGRAM

Logistics discussion

  • Welcome to NASA Ames (view video)
    • Dr. Steven Zornetzer, Associate Director for Research and Technology, NASA Ames Research Center

  • Introduction to NASA's Centennial Challenges Program (view video)
    • Monsi Roman, Director, NASA Centennial Challenges Program

  • Introduction to the CASIS Innovations in Space Award (view video)
    • Jana Stoudemire, Life Sciences Lead, CASIS

  • Methuselah Foundation - Investing to extend healthy life (view video)
    • David Gobel, CEO, Methuselah Foundation

  • Introduction to the New Organ Alliance (view video)
    • Joshua Neubert, Managing Partner, New Organ Alliance

  • A Roadmap to End the Organ Shortage (view video)
    • Introduction to the New Organ Alliance's Roadmapping Initiative and our workshop's roundtables discussions and goals
      • Dr. Scott Collins, CTO TeVido Biodevices; New Organ Alliance Advisory Board

SESSION 1: STATE OF THE ART IN THICK-TISSUE VASCULARIZATION

CHAIR JOSHUA NEUBERT

  • Developing Organovo's Commercial Tissues (view video)
    • Dr. Keith Murphy, CEO, Organovo

  • Roadmapping Roundtable Discussions 1: Challenges in Achieving Thick Tissue Vascularization
    • During this first Roadmapping session we will discuss the current state-of-the-art technologies and identify the research pathways and challenges in achieving thick-tissue vascularization. We will identify specific challenges still remaining on the path toward thick-tissue vascularization
      • Roundtable Facilitators lead discussions at tables.

  • Overview of technologies advancing additive manufacturing for health. (view video)
    • The fabrication of thick-tissues with embedded vascular networks is of great importance to advancing tissue engineering, this presentation will provide an overview of how 3D bioprinting technologies are advancing in this area.
      • Dr. Yong Huang, University of Florida

SESSION 2: VTC TEAM PRESENTATIONS

CHAIR MONSI ROMAN

The Challenges of Vascularizing Engineered Heart Tissue

  • Dr. Ming-Sing Si, University of Michigan, VTC Team Leader

Wake Forest University's Bioprinting Capabilities

  • Dr. Sang-jin Lee, Wake Forest University, VTC Team Leader

Penn State University, VTC Team Presentation

  • Dr. Ibrahim Ozbolat, Penn State University, VTC Team Leader

SESSION 3: ROADMAPPING ROUNDTABLES 2: OVERCOMING CHALLENGES

CHAIR SCOTT COLLINS

Roadmapping Roundtables 2: Overcoming the Challenges

  • This Roadmapping session will explore the specific tools and techniques that researchers may use to overcome the challenges along each research pathway to achieve thick-tissue vascularization, and begin looking beyond this technology toward its end-products for use in the marketplace.
    • Roundtable Facilitators lead discussions at tables

SESSION 4: VTC TEAM PRESENTATIONS

CHAIR MONSI ROMAN


  • Florida Institute of Technology, VTC Team Presentation (view video)
    • Dr. Kunal Mitra, Florida Institute of Technology, VTC Team Leader

  • Rice University, VTC Team Presentation
    • Dr. Jordan Miller, Rice University, VTC Team Leader

SESSION 5: ROADMAPPING ROUNDTABLES 3: BEYOND THICK TISSUE VASCULARIZATION

CHAIR SCOTT COLLINS

  • Roundtable Discussions 3: Beyond Thick Tissue Vascularization 
    • This Roadmapping session will focus discussions on defining End-Products for tissue engineering technologies and their benefits and applications. Discussions will also focus on defining the research pathways available in using thick-tissue vascularization technologies to get to these end-product and explore how current research efforts in achieving thick-tissue vascularization could impact the future opportunities to get to specific end-products.
      • Roundtable Facilitators lead discussions at tables

SESSION 6: ALTERNATIVE OPPORTUNITIES USING MICROGRAVITY FOR TISSUE ENGINEERING

CHAIR JANA STOUDEMIRE


  • Panel: CASIS Innovations in Space Award & other Opportunities with Microgravity (view video)
    • This panel explores key scientific results from past microgravity research, and helps workshop participants understand how the microgravity environment may benefit their future tissue engineering research. We will also examine new research opportunities in microgravity such as the "CASIS Innovations in Space Award" and will help tissue engineering researchers understand how to take advantage of these opportunities.
      • Jana Stoudemire, CASIS (Moderator)
        • Dr. Michael Roberts, Deputy Chief Scientist, CASIS
        • Dr. Kirt Costello, NASA

SESSION 7: ALTERNATIVE OPPORTUNITIES USING COMPUTER MODELING, IMAGE PROCESSING, AND DATA ANALYTICS

CHAIR IOANA COZMUTA


  • Panel: Alternative Opportunities with Computer Modeling, Imaging and Data Analytics. (view video)
    • Tissue engineering research is ultimately an integrative biomedicine problem that’s becoming more and more reliant on multiple sources of information spanning image acquisition and processing, mathematical and computational models of biological systems (from tissue level to cell level and ultimately to the molecular level), genomic patterns, clinical pathology, personalized health records, etc. These sources of information create extremely large data sets and require innovative analytic approaches and tools to extract meaningful information. This panel will discuss how computer modeling, advanced imaging, big-data, machine learning, and other innovative areas of technology provide future opportunities and solutions of relevance to tissue engineering research and in particular to the Vascular Tissue Challenge.
      • Dr. Ioana Cozmuta (Moderator)
        • Dr. Liesbet Geris, Virtual Physiological Human
        • Dr. Patricia Parsons-Wingerter, NASA
        • Kaiser Permanente (Invited)

Day 2

SESSION 8: ROADMAPPING REVIEW

JOSHUA NEUBERT


  • Roadmap Review from Roundtable Chairs (view video)
    • Roundtable chairs and facilitators will share key points about the challenges, research pathways, and opportunities from their previous discussions.
      • Roundtable Chairs

SESSION 9: Investing in the Future

CHAIR LINA CONSTANTINOVICI

  • Panel: Challenges in Funding the Future of Tissue Engineering (view video)
    • Startup companies and research groups discuss some of the challenges in getting the funding needed to get to the end goals of thick-tissue engineering. How are they trying to overcome this and what are the key challenges in the way?
      • Lina Constantinovici (Moderator)
        • Dr. Maria Rapoza, Duke University
        • Dr. Scott Collins, TeVido Biodevices

  • Roundtables: Discussion on challenges funding
    • Discussions and Q&A about how we can improve the funding landscape to start getting more research to the product stage.
      • Roundtable Chairs

  • Panel: Government Funding Model Case Studies (view video)
    • This session will explore how research in tissue engineering is currently being supported by government agencies. It will explore alternative/non-traditional funding models, and how to overcome the challenges in support to get thick-tissue engineering to its end-products.
      • Lina Constantinovici (Moderator)
        • Dr. Michele Grimm, NSF BME
        • Dr. Martha Lundberg, NIH NHLBI
        • Dr. Lucie Low, NIH NCATS
        • Dr. Wendy Dean, DoD USAMRMC
        • Dr. Seila Selimovic, NIH NIBIB

  • Roundtables: Discussions on Government funding models
    • Discussions and Q&A about how we can improve the funding landscape to start getting more research to the product stage.
      • Roundtable Chairs

  • Panel: Investor & Philanthropy Funding Model Case Studies
    • This session will explore how research in tissue engineering is currently being supported by philanthropies and investors. It will explore alternative/non-traditional funding, and how to overcome the challenges in support to get thick-tissue engineering to its end-products.
      • Lina Constantinovici (Moderator)
        • David Gobel, Methuselah Foundation
        • Lux Research (Invited)
        • Other Investors & Philanthropic leaders

  • Roundtable Discussions: Discussions on enhancing the funding landscape with investors and philanthropists
    • Discussions and Q&A about how we can improve the funding landscape to start getting more research to the product stage.
      • Roundtable Chairs

Closing Program

  • Roundtable Discussions: Take-away points and next step opportunities
    • Closing review of next steps and key summary of points. Have everyone at the roundtables go around a circle and discuss key take-away points, and next step action items they would like to see with this Roadmapping initiative and the VT Challenge work.
      • Roundtable Chairs

  • New Organ Alliance & VT Challenge pathways forward (view video)
    • Closing information about New Organ Alliance and VT Challenge next steps.
      • Joshua Neubert, Managing Partner, New Organ Alliance

Organizing Committee

Lt. Col. Luis Alvarez

Academy Professor & Director, Center for Molecular Science, U.S Military Academy; Founding Principal Investigator, Regenerative Biology Group, National Cancer Institute

Dr. Scott Collins

CTO, TeVido Biodevices
New Organ Alliance, Roadmap Chair

Dr. Ioana Cozmuta

Industry Innovation & Microgravity Lead,
NASA, Space Portal Office

Dr. Wendy Dean

Medical Officer, DoD USAMRMC
VT Challenge, Judging Committee

Mr. David Gobel

CEO, Methuselah Foundation

Dr. Timothy Hammond

Professor, Duke University Veterans Affairs Medical Center

VT Challenge Judging Committee

Mrs. Lynn Harper

Lead for Integrative Studies, NASA Space Portal; NASA Challenge Administrator, VT Challenge.

Dr. Anthony Jeevarajan

Deputy Division Chief, Biomedical Research & Environmental Sciences, NASA JSC

Dr. Armand Keating

Professor, University of Toronto
VT Challenge, Judging Committee

Mr. Joshua Neubert

CEO, Institute of Competition Sciences
Managing Partner, New Organ Alliance

Dr. Maria Rapoza

Executive Director, Duke University
Cardiovascular Research Center

Mrs. Monserrate Roman

Director, NASA Centennial Challenges Program

Dr. Boris Schmalz

Research Associate, Max Planck Institutes
Coordinator, New Organ Alliance

Lina Constantinovici

Founder, Innovation4.4;
Partner, BVC Fund, Founder, Startup Nectar

Mrs. Jana Stoudemire

Life Sciences Lead, Center for the Advancement of Science in Space

Additional Participants

Dr. Keith Murphy

CEO, Organova

Dr. Michael Roberts

Deputy Chief Scientist, CASIS

Dr. Kevin Healy

University of California, Berkeley

Dr. Yunzhi Yang

Stanford University

Dr. Michele Grimm

Program Manager, NSF BME

Dr. Jedd Lewis

Executive Director, Organ Preservation Alliance

Dr. Melanie Matheu

Founder, Prellis Biologics

Dr. David Fyhrie

UC Davis; NSF BMMB

Dr. Brenda Ogle

University of Minnesota

Dr. Yong Huang

University of Florida

Dr. Ngan Huang

Stanford University

Dr. Joseph Wu

Stanford University

Dr. Todd McDevitt

UCSF, Gladstone Institutes

Prize FAQs

What is the purpose of this challenge?

Why a challenge prize?

How does this affect me?

What about organs other than the liver?

Is this a global challenge?

Who will own the winning technologies?

What can I do about the organ crisis?

Can multiple teams win the prize?

How do I register a team?

Who is judging the challenge?

Join The Conversation

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